I have always believed that the sources of human distress lie in an individual’s story and the research facts presented in my recent article ‘A Crazy Idea’ spoke for themselves regarding there being no evidence for a biochemical basis to human misery. Whilst I have no doubt that those professionals who subscribe to the notion of mental illness are well-intentioned, there is the conundrum that they do not appear to have kept abreast of research findings. The position that needs addressing is that physicians either don’t read the research literature or they do read it and ignore it – in both situations there is a case to be answered. It seems that it has taken over two hundred years for psychiatrists to begin to realise that the causes and cures for human desperation be in relationship, not in biochemistry.